Aims: Different occupational environments have serious effects on health and life quality. Paying attention to nurses’ abilities and beliefs in work situation is important not only of keeping them healthy, but also as people who are responsible for health of other society members. This study was performed to compare the religious belief, quality of life and resilience in nurses of special care units and general care units, and also how religious beliefs and quality of life can predict nurses' resilience. Methods: This descriptive-cross sectional study was performed on 288 nurses working in special care units and general care units in all hospitals (public and private) in Urmia city by systematic random sampling. Data collection tools were: 1- Quality of Life Scale (WHOQOL-BREF), 2- Systems of Belief Inventory (SBI-15-R), and 3- Caregiver Burden Inventory (Resilience). Data were analyzed using SPSS version 21 Software. Results: Mean scores of quality of life, resilience, and religious belief showed no significant differences between nurses in two units. Results also showed that quality of life can predict nurses’ resilience. This study concluded that the better nurses’ quality of life leads to increasing their resiliency.