In competition-based and collaboration between global economy organizations, strategic management plays a key role in inter-organizational relations and knowledge transfer between partner organizations is a central issue, without which achieving global goals such as joint innovation is impossible. However, knowledge transfer is not without risk, and organizations may, in the event of knowledge transfer, lose their competitive advantage and transfer their confidential knowledge during the transfer process. This study tries to assist companies to identify and measure the risks of knowledge transfer and ultimately by providing a risk management framework for knowledge transfer help organizations manage inter-organizational relationships by introducing this concept and presenting a conceptual model. In this regard, three factors were determined as the key factors that form the dimensions of the proposed model: “risks of the type of cooperation,” “network-related risks,” “physical adjacency-related risks.” The proposed model was analyzed in industries of Qazvin using a second-order confirmatory factor analysis and modeling structural equation. Examining the results of the proposed model in industry shows that network-type factor is more important.